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2,4'-DDE-d<sub>8</sub>

" in MedChemExpress (MCE) Product Catalog:

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3873

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

107

Biochemical Assay Reagents

116

Peptides

Inhibitory Antibodies

192

Natural
Products

140

Recombinant Proteins

2507

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: MCHR1 (GPR24) P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121779S

2,4’-DDE-d8

Isotope-Labeled Compounds Others

2,4'-DDE-d₈ is the deuterium labeled 2,4’-DDE[1].

2,4’-DDE-d8	Isotope-Labeled Compounds	Others
2,4'-DDE-d₈ is the deuterium labeled 2,4’-DDE[1].

HY-B1986S

*p,p'-DDE-d8* 4,4'-DDE-d<sub>8sub>; p,p'-Dichlorodiphenyldichloroethylene-d<sub>8sub>	Androgen Receptor Drug Metabolite	Endocrinology
p,p'-DDE-d₈ is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-13690S2

Mitotane-d8 2,4′-DDD-d<sub>8sub>; o,p'-DDD-d<sub>8sub>	Apoptosis	Cancer
Mitotane-d₈ is the deuterium labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].

HY-13011S

Alectinib-d8 CH5424802-d<sub>8sub>; RO5424802-d<sub>8sub>; AF802-d<sub>8sub>	Anaplastic lymphoma kinase (ALK)	Cancer
Alectinib-d₈ is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].

HY-W280214S1

Nonylbenzene-d24

1-Phenylnonane-d<sub>24sub>
Isotope-Labeled Compounds Others

Nonylbenzene-d₂₄ is the deuterium labeled Nonylbenzene[1].

Nonylbenzene-d24 1-Phenylnonane-d<sub>24sub>	Isotope-Labeled Compounds	Others
Nonylbenzene-d₂₄ is the deuterium labeled Nonylbenzene[1].

HY-18572S

2,4-D-13C6 2,4-Dichlorophenoxyacetic acid-¹³C<sub>6sub>	Isotope-Labeled Compounds DNA/RNA Synthesis	Others
2,4-D- ¹³C₆ is the ¹³C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[1].

HY-W009981S

*1-Bromo-2,4-difluorobenzene-d3* 2,4-Difluorobromobenzene-d<sub>3sub>	Isotope-Labeled Compounds	Others
1-Bromo-2,4-difluorobenzene-d₃ is the deuterium labeled 1-Bromo-2,4-difluorobenzene[1].

HY-W010420S

2,4-Difluoro-1-methylbenzene-d3 2,4-Difluorotoluene-d<sub>3sub>	Isotope-Labeled Compounds	Others
2,4-Difluoro-1-methylbenzene-d₃ is the deuterium labeled 2,4-Difluoro-1-methylbenzene[1].

HY-P5571

Aurein 2.4

Antibiotic Bacterial Infection

Aurein 2.4 is an antibiotic antimicrobial peptide. Aurein 2.4 is active against Gram-positive bacterial .

Aurein 2.4	Antibiotic Bacterial	Infection
Aurein 2.4 is an antibiotic antimicrobial peptide. Aurein 2.4 is active against Gram-positive bacterial .

HY-W001955S

2-(4-Fluorophenyl)acetic acid-d2 p-Fluorophenylacetic acid-d<sub>2sub>	Isotope-Labeled Compounds	Others
2-(4-Fluorophenyl)acetic acid-d₂ is the deuterium labeled 2-(4-Fluorophenyl)acetic acid[1].

HY-W014779S

Dodecane-1,12-diol-d24

Dodecamethylene glycol-d<sub>24sub>
Isotope-Labeled Compounds Others

Dodecane-1,12-diol-d₂₄ is the deuterium labeled Dodecane-1,12-diol[1].

Dodecane-1,12-diol-d24 Dodecamethylene glycol-d<sub>24sub>	Isotope-Labeled Compounds	Others
Dodecane-1,12-diol-d₂₄ is the deuterium labeled Dodecane-1,12-diol[1].

HY-W014223S1

*(2,4-Dihydroxyphenyl)(phenyl)methanone-d5* Ultraviolet absorber UV-0-d<sub>5sub>	Isotope-Labeled Compounds	Others
(2,4-Dihydroxyphenyl)(phenyl)methanone-d₅ is the deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone[1].

HY-B0615AS

Moricizine-d8(Hydrochloride) EN 313-d<sub>8sub>; Ethmozin-d<sub>8sub>; Moracizine-d<sub>8sub>	Isotope-Labeled Compounds	Cardiovascular Disease
Moricizine-d₈ (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1][2].

HY-G0021S

N-Desmethylclozapine-d8 Norclozapine-d<sub>8sub>; Desmethylclozapine-d<sub>8sub>; Normethylclozapine-d<sub>8sub>	mAChR Opioid Receptor Drug Metabolite Virus Protease	Infection
N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride Norclozapine-d<sub>8sub> hydrochloride; Desmethylclozapine-d<sub>8sub> hydrochloride; Normethylclozapine-d<sub>8sub> hydrochloride	mAChR Opioid Receptor Drug Metabolite Virus Protease	Infection
N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

HY-17037S1

Pirenzepine-d8 dihydrochloride LS 519-d<sub>8sub> dihydrochloride; Pirenzepin-d<sub>8sub> dihydrochloride; Gastrozepin-d<sub>8sub> dihydrochloride	Isotope-Labeled Compounds	Cancer
Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-23506S

*1-Aminoimidazolidine-2,4-dione-13C3* 1-Amino hydantoin-¹³C<sub>3sub>	Isotope-Labeled Compounds	Others
1-Aminoimidazolidine-2,4-dione- ¹³C₃ is ¹³C labeled 1-Aminoimidazolidine-2,4-dione.

HY-17037S

Pirenzepine-d8 LS 519-d<sub>8sub> free base; Pirenzepin-d<sub>8sub>; Gastrozepin-d<sub>8sub>	Isotope-Labeled Compounds mAChR	Neurological Disease Inflammation/Immunology
Pirenzepine-d₈ is the deuterium labeled Pirenzepine dihydrochloride. Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.

HY-10227S

Bortezomib-d8 PS-341-d<sub>8sub>; LDP-341-d<sub>8sub>; NSC 681239-d<sub>8sub>	Proteasome NF-κB Apoptosis Autophagy	Cancer
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].

HY-13463BS

Avatrombopag-d8 hydrochloride AKR-501-d<sub>8sub> hydrochloride; E5501-d<sub>8sub> hydrochloride; YM477-d<sub>8sub> hydrochloride	Isotope-Labeled Compounds Thrombopoietin Receptor	Cardiovascular Disease
Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].

HY-14740S

Elvitegravir-d8 GS-9137-d<sub>8sub>; JTK-303-d<sub>8sub>; D06677-d<sub>8sub>	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-15531S

Venetoclax-d8 ABT-199-d<sub>8sub>; GDC-0199-d<sub>8sub>; RG7601-d<sub>8sub>	Bcl-2 Family Autophagy	Cancer
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

HY-15581S

MMAD-d8 Demethyldolastatin 10-d<sub>8sub>; Monomethylauristatin D-d<sub>8sub>; Monomethyl Dolastatin 10-d<sub>8sub>	ADC Cytotoxin Microtubule/Tubulin	Cancer
MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

HY-Y1309S

1-Naphthol-d8 Furro ER-d<sub>8sub>; NSC 9586-d<sub>8sub>; Nako TRB-d<sub>8sub>	Endogenous Metabolite	Others
1-Naphthol-d₈ is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].

HY-B0272S1

Rifampicin-d8 Rifampin-d<sub>8sub>; Rifamycin AMP-d<sub>8sub>	Bacterial Influenza Virus Antibiotic	Infection
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-N0378S

D-Mannitol-d8 Mannitol-d<sub>8sub>; Mannite-d<sub>8sub>	Endogenous Metabolite Apoptosis	Metabolic Disease
D-Mannitol-d₈ is the deuterium labeled D-Mannitol. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

HY-13502S

Mitoxantrone-d8 Mitozantrone-d<sub>8sub>; NSC 301739-d<sub>8sub>	Isotope-Labeled Compounds Topoisomerase PKC	Cancer
Mitoxantrone-d₈ (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].

HY-N0007S

Bisdemethoxycurcumin-d8 Curcumin III-d<sub>8sub>; Didemethoxycurcumin-d<sub>8sub>	Apoptosis Autophagy	Cancer
Bisdemethoxycurcumin-d₈ is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.

HY-N0623S5

L-Tryptophan-d8 Tryptophan-d<sub>8sub>; Tryptophane-d<sub>8sub>	Endogenous Metabolite	Metabolic Disease
L-Tryptophan-d₈ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-B0246S2

Carbamazepine-d8 CBZ-d<sub>8sub>; NSC 169864-d<sub>8sub>	Sodium Channel Autophagy Mitophagy	Neurological Disease Cancer
Carbamazepine-d₈ is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC50 of 131 μM[1][2].

HY-34444S

1,1-Dioxothiolan-d8 Bondelane A-d<sub>8sub>; Cyclic tetramethylene sulfone-d<sub>8sub>; Cyclotetramethylene sulfone-d<sub>8sub>	Isotope-Labeled Compounds	Others
1,1-Dioxothiolan-d₈ is the deuterium labeled 1,1-Dioxothiolan[1].

HY-B1955S

4',4-Dibromobiphenyl-d8 NSC 2098-d<sub>8sub>; PBB 15-d<sub>8sub>; p,p'-Dibromobiphenyl-d<sub>8sub>	Isotope-Labeled Compounds	Others
4',4-Dibromobiphenyl-d₈ is the deuterium labeled 4',4-Dibromobiphenyl[1].

HY-107434S

Molindone-d8 (±)-Molindone-d<sub>8sub>; SPN-810M-d<sub>8sub>	Isotope-Labeled Compounds Dopamine Receptor	Neurological Disease
Molindone-d₈ is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses[1][2].

HY-13593S

Chlorambucil-d8 CB-1348-d<sub>8sub>; WR-139013-d<sub>8sub>	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-B0400S

D-Sorbitol-d8 Sorbitol-d<sub>8sub>; D-Glucitol-d<sub>8sub>	Endogenous Metabolite	Others
D-Sorbitol-d₈ is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1].

HY-G0016S2

N-Acetyl dapsone-d8

MADDS-d<sub>8sub>; Monoacetyldapsone-d<sub>8sub>
Isotope-Labeled Compounds Others

N-Acetyl Dapsone-d₈ is the deuterium labeled N-Acetyl Dapsone[1].

N-Acetyl dapsone-d8 MADDS-d<sub>8sub>; Monoacetyldapsone-d<sub>8sub>	Isotope-Labeled Compounds	Others
N-Acetyl Dapsone-d₈ is the deuterium labeled N-Acetyl Dapsone[1].

HY-17401S

Ranolazine-d8 dihydrochloride CVT 303-dd<sub>8sub> dihydrochloride; RS 43285-d<sub>8sub>	Calcium Channel Sodium Channel Autophagy	Cardiovascular Disease Cancer
Ranolazine-d₈ (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].

HY-10162S1

Olaparib-d8 AZD2281-d<sub>8sub>; KU0059436-d<sub>8sub>	PARP Autophagy Mitophagy	Cancer
Olaparib-d₈ is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

HY-100665S

Dehydroaripiprazole-d8 OPC-14857-d<sub>8sub>; DM-14857-d<sub>8sub>	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Dehydroaripiprazole-d₈ is deuterium labeled Dehydroaripiprazole. Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole[1][2][3].

HY-14667S

Lomitapide-d8 AEGR-733-d<sub>8sub>; BMS-201038-d<sub>8sub>	Isotope-Labeled Compounds	Cardiovascular Disease
Lomitapide-d₈ is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.

HY-B1895S

Levodropropizine-d8 (S)-(-)-Dropropizine-d<sub>8sub>; DF-526-d<sub>8sub>	Isotope-Labeled Compounds Histamine Receptor	Inflammation/Immunology Endocrinology
Levodropropizine-d₈ is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.

HY-132386S

Imatinib-d8 mesylate STI571-d<sub>8sub> mesylate; CGP-57148B-d<sub>8sub> mesylate	Isotope-Labeled Compounds	Others
Imatinib-d₈ (mesylate) is the deuterium labeled Imatinib mesylate[1].

HY-15463S

Imatinib-d8 1 Publications Verification STI571-d<sub>8sub>; CGP-57148B-d<sub>8sub>	Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy	Cancer
Imatinib-d₈ is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

HY-B0688S

Dapsone-d8 4,4′-Diaminodiphenyl sulfone-d<sub>8sub>; DDS-d<sub>8sub>	Antibiotic Parasite Bacterial Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

HY-12522S

PF-06380101-d8 2 Publications Verification Aur0101-d<sub>8sub>; Auristatin-0101-d<sub>8sub>	Microtubule/Tubulin ADC Cytotoxin	Cancer
PF-06380101-d₈ is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue[1].

HY-W009247S

N-Desmethylolanzapine-d8

N-Demethylolanzapine-d<sub>8sub>; LY170055-d<sub>8sub>
Isotope-Labeled Compounds Others

N-Desmethylolanzapine-d₈ is deuterium labeled N-Desmethylolanzapine.
HY-W127572

Glycerol-d8

1,2,3-Propanetriol-d<sub>8sub>; Glycerin-d<sub>8sub>
Isotope-Labeled Compounds Others

Glycerol-d₈ is the deuterium labeled Glycerol[1].

HY-12678S1

Entrectinib-d8 NMS-E628-d<sub>8sub>; RXDX-101-d<sub>8sub>	Isotope-Labeled Compounds Autophagy Anaplastic lymphoma kinase (ALK) Trk Receptor ROS Kinase	Cancer
Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5 Publications Verification	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-18572

2,4-D 2,4-Dichlorophenoxyacetic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields Biological Pesticide Research Agricultural Research	DNA/RNA Synthesis Apoptosis
2,4-D (2, 4-dichlorophenoxyacetic acid) is a selective herbicide that can be orally active for the control of broad-leaved weeds. 2,4-D can induce apoptosis. 2,4-D inhibits DNA and protein synthesis, thereby preventing normal plant growth and development .

HY-N10455

24-Epicastasterone 1 Publications Verification 24-epi-Castasterone	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Other Diseases Brassinolide Phytohormone Disease Research Fields Agricultural Research	Others
24-Epicastasterone (24-epi-Castasterone), a brassinosteroid, is a nature product that could be isolated from Hydrodictyon reticulatwn .

HY-W014589

2,4-Di-tert-butylphenol 2,4-DTBP	Monophenols Microorganisms Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2,4-Di-tert-butylphenol is an endogenous metabolite.

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-W007539

2,4-Dihydroxybenzaldehyde	Monophenols Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2,4-Dihydroxybenzaldehyde is an endogenous metabolite.

HY-W015618

2',4'-Dimethylacetophenone	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2',4'-Dimethylacetophenone is an endogenous metabolite.

HY-N0853A

Alisol A 24-acetate Alisol A 24-monoacetate; Alisol A monoacetate	Triterpenes Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Source classification Other Diseases Plants Alismataceae Disease Research Fields	Others
Alisol A 24-acetate (Alisol A 24-monoacetate) is a natural product.

HY-N12467

24-Methylcholesterol	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
24-Methylcholesterol is a trans-ferulate ester that can be isolated from rice bran. 24-Methylcholesterol significantly inhibited TPA-induced inflammation .

HY-W011474

Geranylgeraniol	Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-N3661

(24S)-Cycloartane-3β,24,25-triol	Triterpenes Structural Classification Terpenoids Source classification Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae	Bacterial
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .

HY-137330

*S-(2,4-Dinitrophenyl)glutathione*	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
S-(2,4-Dinitrophenyl)glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl)glutathione can be used as an irreversible glutathione reductase inhibitor with an K_i value of 30 µM .

HY-133968

24-Methylenecholesterol Ostreasterol	Structural Classification Classification of Application Fields Anti-aging Source classification Marine natural products Other marine organisms Plants other families Microorganisms Animals Inflammation/Immunology Disease Research Fields Steroids	Acyltransferase
24-Methylenecholesterol (Ostreasterol), a natural marine sterol, stimulates cholesterol acyltransferase in human macrophages. 24-Methylenecholesterol possess anti-aging effects in yeast. 24-methylenecholesterol enhances honey bee longevity and improves nurse bee physiology .

HY-N8122

24-Methylenecycloartanyl ferulate	Triterpenes Structural Classification Monophenols other families Classification of Application Fields Terpenoids Source classification Phenols Plants Disease Research Fields Cancer	Akt
24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive Akt1 inhibitor (EC₅₀= 33.3μM) .

HY-N1704

24-Methylenecycloartanol acetate	Euphorbia segetalis L. Triterpenes Structural Classification Terpenoids Source classification Euphorbiaceae Plants	Others
24-Methylenecycloartanol acetate is a triterpene that can be found in Euphorbia segetalis .

HY-107315

Alisol F 24-acetate	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Terpenoids Source classification Plants Alismataceae	HBV Apoptosis
Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC₅₀ values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research .

HY-Y0694

2',4'-Dihydroxyacetophenone Resacetophenone; 1-(2,4-Dihydroxyphenyl)ethanone	Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. A plant metabolite.

HY-W012575

2,4-Dihydroxybenzoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2,4-Dihydroxybenzoic acid is a degradation product of cyaniding glycoside from tart cheeries in cell culture.

HY-66047

2,4-Dihydroxypyrimidine-5-carboxylic Acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2,4-Dihydroxypyrimidine-5-carboxylic Acid is an endogenous metabolite.

HY-N1668

2,4-Dihydroxyphenylacetic acid	Structural Classification Source classification Ranunculaceae Phenols Polyphenols Plants Nigella damascena Linn.	Others
2,4-Dihydroxyphenylacetic acid (compound 3) is a natural product that can be obtained from Nigella damascene L. seeds .

HY-18646

23,25-Dihydroxy-24-oxovitamin D3 24-Oxo-23,25-dihydroxyvitamin D3	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
23,25-Dihydroxy-24-oxovitamin D3 is a major metabolite of 24(R),25-Dihydroxyvitamin D3. 23,25-Dihydroxy-24-oxovitamin D3 can be used for the research of metabolic diseases .

HY-N8888

10,11-Dihydro-24-hydroxyaflavinine	Natural Products Animals Source classification	Others
10,11-Dihydro-24-hydroxyaflavinine (10,23,24,25-tetrahydro-24-hydroxyaflavinine), an aflavinine analog, is a natural product that can be isolated from Ascostromata of Eupenicillium crustaceum .

HY-N7516

*4'-Hydroxy-2,4-dimethoxychalcone*	Infection Flavonoids Chalcones Monophenols Classification of Application Fields Source classification Phenols Plants Umbelliferae Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Parasite Bacterial Fungal
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity .

HY-32343

Secalciferol 3 Publications Verification (24R)-24,25-Dihydroxyvitamin D3	Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology Steroids	Endogenous Metabolite VD/VDR
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system .

HY-W013627

*trans,trans-2,4-Decadienal*	Natural Products other families Microorganisms Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields	Others
trans,trans-2,4-Decadienal is a lipid peroxidation product of linolieic acid .

HY-107238

(3β,24R)-3-(Acetyloxy)eupha-7,25-dien-24-ol	Triterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Plants Moraceae Disease Research Fields Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat	Others
(3β,24R)-3-(Acetyloxy)eupha-7,25-dien-24-ol is an euphane triterpene compound isolated from the barks of Broussonetia papyrifera .

HY-N2370

24-Hydroxycholesterol	Structural Classification Animals Source classification Steroids	iGluR LXR
24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

HY-N11512

α-Glucosidase-IN-24	Structural Classification Polysaccharides Source classification Gentianaceae Plants Saccharides Swertia kouitchensis Franch.	Glucosidase
α-Glucosidase-IN-24 (Compound 13) is an α-Glucosidase inhibitor with an IC₅₀ of 451 μM. α-Glucosidase-IN-24 can be isolated from Swertia kouitchensis .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N11034

24-Hydroxy-licorice-saponin A3	Triterpenes Structural Classification Leguminosae Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch.	Others
24-Hydroxy-licorice-saponin A3 is an oleanane-type triterpene saponin (OTS). 24-Hydroxy-licorice-saponin A3 can be isolated from G. uralensis. .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-N6262

20(S),24(R)-Ocotillol	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Araliaceae	Others
20(S),24(R)-Ocotillol is isolated from Panax ginseng .

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Disease Research Fields Selaginella tamariscina (P. Beauv.) Spring Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-N1665

2',4'-Dihydroxy-3',6'-dimethoxychalcone	Flavonoids Chalcones Classification of Application Fields Polygonaceae Source classification Phenols Polyphenols Plants Disease Research Fields Perilla ocimoides L. Cancer	Others
2',4'-Dihydroxy-3',6'-dimethoxychalcone is a natural product that can be isolated from Polygonum Lapathifolium. 2',4'-Dihydroxy-3',6'-dimethoxychalcone inhibits the growth of CCRF-CEM leukaemia cells and CEM/ADR5000 cells, with IC₅₀ values of 10.67 and 18.60 μM, respectively .

HY-W004206

2-(4-Methoxyphenyl)acetic acid 4-Methoxyphenylacetic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
2-(4-Methoxyphenyl)acetic acid is a plasma metabolite, with high sensitivity and specificity value as a biomarker for discriminating between NSCLC and healthy controls.

HY-N11650

(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Bacterial
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) is an antitubercular agent with MIC value of 12.5 μg/mL for Mycobacterium tuberculosis H37Ra. (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid shows cytotoxicity with IC₅₀ value of 32 μM for Vero cells .

HY-N9944

3-Oxo-4,6-choladien-24-oic acid	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
3-Oxo-4,6-choladien-24-oic acid is an endogenous metabolite. 3-Oxo-4,6-choladien-24-oic acid exsists in the urine of patients with hepatobiliary disease .

HY-N1667

2',4'-Dihydroxy-6'-Methoxyacetophenone	Structural Classification Piscidia erythrina L. Source classification Phenols Polyphenols Plants Compositae	Parasite
2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone from Artemisia annua. Artemisia annua is an analog of Artemisinin that is effective in the research of malaria .

HY-W012952

*(2E,4E)-Hepta-2,4-dienal* trans,trans-2,4-Heptadienall	Structural Classification Natural Products Vaccinium macrocarpon Aiton Source classification Plants Ericaceae	Biochemical Assay Reagents
(2E,4E)-Hepta-2,4-dienal is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N11089

23,24-Dihydroisocucurbitacin D	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Trichosanthes cucumeroides (Ser.) Maxim. Plants	Others
23,24-Dihydroisocucurbitacin D (compound 22) is a cucurbitacin .

HY-N3658

Cycloart-25-ene-3β,24-diol	Triterpenes Structural Classification Terpenoids Source classification Euphorbiaceae Euphorbia pulcherrima Willd. ex Klotzsch Plants	Others
Cycloart-25-ene-3β,24-diol is a natural triterpene .

HY-101414

L-DABA L-2,4-Diaminobutyric acid	Classification of Application Fields Neurological Disease Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	GABA Receptor Endogenous Metabolite
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-N1664

2',4'-Dihydroxy-2,3',6'-trimethoxychalcone	Flavonoids Chalcones Classification of Application Fields Labiatae Source classification Other Diseases Phenols Polyphenols Ulmus davidiana var. japonica (Rehd.)Nakai Plants Disease Research Fields	Others
2',4'-Dihydroxy-2,3',6'-trimethoxychalcone, a flavonoid, is a natural product that can be isolated from the roots of Scutellaria Luzonicatropical .

HY-N1647

*2',3',6-Trihydroxy-2,4-dimethoxybenzophenone*	Structural Classification Source classification Guttiferae Phenols Polyphenols Plants Garcinia subelliptica	Others
2',3',6-Trihydroxy-2,4-dimethoxybenzophenone (compound 1) is a benzophenone derivative, that can be isolated from the herbs of Garcinia xanthochymus .

HY-W040264

24,25-Dihydrolanosterol Lanostenol	Triterpenes Capsicum annuum L. Classification of Application Fields Terpenoids Source classification Other Diseases Plants Solanaceae Disease Research Fields	Others
24,25-Dihydrolanosterol (Lanostenol) is a component of the seeds of red pepper (Capsicum annuum) .

HY-N1683

20(S),24(S)-Dihydroxydammar-25-en-3-one	Triterpenes Structural Classification Terpenoids Source classification Betula platyphylla Suk. Plants Betulaceae	Others
20(S),24(S)-Dihydroxydammar-25-en-3-one (compound 19) is a kind of triterpene. 20(S),24(S)-Dihydroxydammar-25-en-3-one can be isolated from the floral spikes of Betula platyphylla var. 20(S),24(S)-Dihydroxydammar-25-en-3-one has cytotoxicity against Human Cancer Cell Lines .

HY-101414A

L-DABA hydrobromide L-2,4-Diaminobutyric acid hydrobromide	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite GABA Receptor
L-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week GABA transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-N11511

3α-Acetoxyurs-5:12-dien-24-oic acid	Triterpenes Structural Classification Terpenoids Source classification Boswellia sacra Flück. Coumarins Phenylpropanoids Plants Burseraceae	Others
3α-Acetoxyurs-5:12-dien-24-oic acid is a natural product that can be isolated from Boswellia sacra Fluckiger .

HY-N1687

21,24-Epoxycycloartane-3,25-diol	Triterpenes Structural Classification Terpenoids Lansium domesticum Corrêa Source classification Plants Meliaceae	Others
21,24-Epoxycycloartane-3,25-diol (compound 15 or 16) is a cycloartanoid triterpene that can be isolated from the leaves of Lansium domesticum. 21,24-Epoxycycloartane-3,25-diol inhibits skin-tumor promotion .

HY-136177

*Tris(2,4-di-tert-butylphenyl)phosphate*	Natural Products Verbenaceae Source classification Plants Disease Research Fields Inflammation/Immunology Vitex negundo Linn.	Phospholipase
Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A₂ (sPLA₂) through molecular docking .

Cat. No.	Product Name	Chemical Structure

HY-121779S

2,4’-DDE-d8

2,4'-DDE-d₈ is the deuterium labeled 2,4’-DDE[1].

HY-B1986S

*p,p'-DDE-d8*
p,p'-DDE-d₈ is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].

HY-13690S2

Mitotane-d8

Mitotane-d₈ is the deuterium labeled Mitotane[1]. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions[2][3][4][5].

HY-13011S

Alectinib-d8
Alectinib-d₈ is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].

HY-W280214S1

Nonylbenzene-d24

Nonylbenzene-d₂₄ is the deuterium labeled Nonylbenzene[1].

HY-18572S

2,4-D-13C6
2,4-D- ¹³C₆ is the ¹³C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development[1].

HY-W009981S

1-Bromo-2,4-difluorobenzene-d3

1-Bromo-2,4-difluorobenzene-d₃ is the deuterium labeled 1-Bromo-2,4-difluorobenzene[1].
HY-W010420S

2,4-Difluoro-1-methylbenzene-d3

2,4-Difluoro-1-methylbenzene-d₃ is the deuterium labeled 2,4-Difluoro-1-methylbenzene[1].
HY-W001955S

2-(4-Fluorophenyl)acetic acid-d2

2-(4-Fluorophenyl)acetic acid-d₂ is the deuterium labeled 2-(4-Fluorophenyl)acetic acid[1].
HY-W014779S

Dodecane-1,12-diol-d24

Dodecane-1,12-diol-d₂₄ is the deuterium labeled Dodecane-1,12-diol[1].
HY-W014223S1

(2,4-Dihydroxyphenyl)(phenyl)methanone-d5

(2,4-Dihydroxyphenyl)(phenyl)methanone-d₅ is the deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone[1].

HY-B0615AS

Moricizine-d8(Hydrochloride)
Moricizine-d₈ (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period[1][2].

HY-G0021S

N-Desmethylclozapine-d8

N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride

N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-23506S

1-Aminoimidazolidine-2,4-dione-13C3

1-Aminoimidazolidine-2,4-dione- ¹³C₃ is ¹³C labeled 1-Aminoimidazolidine-2,4-dione.
HY-17037S

Pirenzepine-d8

Pirenzepine-d₈ is the deuterium labeled Pirenzepine dihydrochloride. Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.

HY-10227S

Bortezomib-d8
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].

HY-13463BS

Avatrombopag-d8 hydrochloride

Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].

HY-14740S

Elvitegravir-d8
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-15531S

Venetoclax-d8
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

HY-15581S

MMAD-d8

MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.
HY-Y1309S

1-Naphthol-d8

1-Naphthol-d₈ is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].

HY-B0272S1

Rifampicin-d8
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-N0378S

D-Mannitol-d8

D-Mannitol-d₈ is the deuterium labeled D-Mannitol. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

HY-13502S

Mitoxantrone-d8
Mitoxantrone-d₈ (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM[1][2].

HY-N0007S

Bisdemethoxycurcumin-d8
Bisdemethoxycurcumin-d₈ is the deuterium labeled Bisdemethoxycurcumin. Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.

HY-N0623S5

L-Tryptophan-d8
L-Tryptophan-d₈ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].

HY-B0246S2

Carbamazepine-d8

Carbamazepine-d₈ is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC50 of 131 μM[1][2].
HY-34444S

1,1-Dioxothiolan-d8

1,1-Dioxothiolan-d₈ is the deuterium labeled 1,1-Dioxothiolan[1].
HY-B1955S

4',4-Dibromobiphenyl-d8

4',4-Dibromobiphenyl-d₈ is the deuterium labeled 4',4-Dibromobiphenyl[1].

HY-107434S

Molindone-d8
Molindone-d₈ is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses[1][2].

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

HY-B0400S

D-Sorbitol-d8
D-Sorbitol-d₈ is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1].

HY-G0016S2

N-Acetyl dapsone-d8

N-Acetyl Dapsone-d₈ is the deuterium labeled N-Acetyl Dapsone[1].

HY-17401S

Ranolazine-d8 dihydrochloride

Ranolazine-d₈ (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].

HY-10162S1

Olaparib-d8
Olaparib-d₈ is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

HY-100665S

Dehydroaripiprazole-d8
Dehydroaripiprazole-d₈ is deuterium labeled Dehydroaripiprazole. Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole[1][2][3].

HY-14667S

Lomitapide-d8
Lomitapide-d₈ is deuterium labeled Lomitapide. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.

HY-B1895S

Levodropropizine-d8
Levodropropizine-d₈ is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.

HY-132386S

Imatinib-d8 mesylate

Imatinib-d₈ (mesylate) is the deuterium labeled Imatinib mesylate[1].

HY-15463S

Imatinib-d8 1 Publications Verification
Imatinib-d₈ is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

HY-B0688S

Dapsone-d8

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

HY-12522S

PF-06380101-d8 2 Publications Verification
PF-06380101-d₈ is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue[1].

HY-W009247S

N-Desmethylolanzapine-d8

N-Desmethylolanzapine-d₈ is deuterium labeled N-Desmethylolanzapine.
HY-W127572

Glycerol-d8

Glycerol-d₈ is the deuterium labeled Glycerol[1].

HY-12678S1

Entrectinib-d8

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC₅₀ values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice .

HY-Y0921S

(±)-1,2-Propanediol-d8
(±)-1,2-Propanediol-d₈ is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.

HY-117605S

N-Desmethyl Sildenafil-d8
N-Desmethyl Sildenafil-d₈ is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2][3].

HY-B0891S

17α-Hydroxyprogesterone-d8
17α-Hydroxyprogesterone-d₈ is the deuterium labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.

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Species:	Human (78) Virus (9) Rhesus Macaque (3) Rat (6) Mouse (28) Cynomolgus (11) E.coli (1) Pig (1)
Tag:	GFP (3) His (90) SUMO (3) Tag Free (13) Strep (4) Avi (12) Myc (3) GST (4) Trx (1) Fc (34)
Source:	HEK293 (84) E. coli Cell-free (6) Sf9 insect cells (9) P. pastoris (4) E. coli (37)


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2,4'-DDE-d<sub>8</sub>

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